Chemotherapeutic Interventions Against Tuberculosis

Chemotherapeutic Interventions Against Tuberculosis

Tuberculosis is the second leading cause of infectious deaths globally. Many effective conventional antimycobacterial drugs have been available, however, emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) has overshadowed the effectiveness of the current first and second line drugs. Further, currently available agents are complicated by s...

Tuberculosis: The Chemotherapeutic Approaches

'[HE' term, chemotherapy of tuberculosis, implies a simplified concept which may have been compromised in the reader's mind by the experience of, successful chemotherapy in other fields. It is not a misplaced pedantry which leads clinicians to speak of the "management" of tuberculosis, but rather a work-a-day acquaintance and understanding of the many diverse pathological conditions involved. T...

In vitro chemotherapeutic combinations against isoniazid-resistant Mycobacterium tuberculosis and Mycobacterium fortuitum.

It is an acceptable medical practice to use second-line antimycobacterial drugs in combination with isoniazid in treatment of isoniazid-resistant tuberculosis. Recent investigations have demonstrated the importance of determining chemotherapeutic interaction in instances of multiple antibiotic use. We studied the inhibitory effect of combinations of isoniazid with ethambutol, rifampin, ethionam...

Study on chemotherapeutic value of imidorazi against sheep babesia infection

  The activity and efficacy of Iranian synthesized imidocarb dipropionate (imidorazi) has been tested against Babesia ovis infection in experimentally and naturally affected sheep. The results indicated that the drug is effective and could be used for treatment of sheep and goats babesiosis. The effectiveness of imidorazi is also similar to the imizol (imidocarb dipropionate) imported from abroad.

Chemotherapeutic Strategies and Targets Against Resistant TB